For industrial products, sodium gluconate is widely used as cement retarder, which can effectively prevent the solidification and caking phenomenon during commercial concrete transportation, and also can be used as surface cleaning agent for iron and steel, special cleaning agent for glass bottles, and corrosion inhibitor. For food-grade and pharmaceutical-grade products, sodium gluconate can regulate human acid-base balance, ensure the normal function of nerves, effectively prevent the occurrence of Low Na syndrome, as food additives and pharmaceutical intermediates. Sodium gluconate has obvious coordination effect, which is suitable for molybdenum, silicon, phosphorus, tungsten, nitrite and other formulations; the corrosion inhibition rate increases with the increase of temperature, the ability of scale inhibition is strong, it has strong complexation ability to calcium, magnesium and ferric salts; as the corrosion inhibitor of circulating cooling water, it is also a great advantage of sodium gluconate.
In the industry generally with glucose-containing substances as raw materials, the fermentation process is made from glucose to glucose acid, and then by sodium hydroxide to neutralize, can be sodium gluconate, can also be used electrolysis and oxidation synthesis. According to the different types of ferment enzymes used, fermentation can be divided into two minutes, one is using Aspergillus niger enzyme, the other is acid, the latter law by the use of glucose dehydrogenation to form lactone, and then the ester decomposition. Sodium gluconate can also be fermented directly from glucose. At this time, the composition of the fermentation base can be: glucose 250-350g/l, magnesium sulfate 0.2-0.3g/l, ammonium dihydrogen phosphate or urea 0.4-0.5g/l. The substrate shall be sterilized. During the fermentation process, the temperature control was 30-32 degrees, and the ph was controlled by $number sodium hydroxide by 5.5-6.5, and the fermentation process continued to 40-100h. Then, by filtration and washing to remove microorganisms, activated carbon decolorization, filtration, concentration results or spray drying finished.